|
Class of biodetector |
Detection system |
Approx.limit of detection,no. of bacteria1 |
size |
Timeto positive ID, min.2 |
Prior knowledge of agent needed?3 |
No. of species screenable in parallel4 |
Detection of biotoxins5 |
|
DNA |
Polymerase chain reaction(PCR) |
10 |
suitcase |
10 |
yes |
64 channels |
no |
|
Magnetic field sensors |
1000 |
suitcase |
10 |
yes |
64 channels |
no |
|
|
Antibody |
Test strips |
100,000 |
briefcase |
10 |
yes |
1 species per strip |
yes |
|
Flow cytometry and optical fibers |
100 |
suitcase |
10 |
yes |
100 withdyed microbeads additional channels possible for optical fibers |
yes |
|
|
Tissue-based |
Fluporescent B cells |
10 |
Lab-based |
1 |
yes |
1, but additional channels possible |
yes |
|
Electrical impedance |
10 |
Hand held |
1 |
no |
any |
yes |
|
|
Mass spectrometry |
1000 |
suitcase |
10 |
no |
any |
yes |
1.- These numbers depend on the agent and test conditions. These numbers are expressed as orders of magnitude
2.- Times are expressed as orders of magnitude
3.- Some methods require an extensive database of threat agents
4.- With the exception of mass spectrometry, these can all be made more parallel by adding channels or arraying cells
5.- Toxins contain no DNA
The Table shows WAYS and MEANS of DETECTING BIOLOGICAL WARFARE AGENTS
MANUEL CEREIJO
|
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